Check with your priest, but historically this has generally been treated very seriously.
I read of a guy who experienced a spill at a monastery on Mt. Athos. The monks restrained him, took his shoe and shirt (probably burned them), another monk picked up every particle of anything in the area of the spill on the tip of his finger and ate it, then came back with a bottle of volatile spirits, doused the area and set it on fire.
I have read of other places where it fell on carpet, someone knelt down and literally sucked as much as possible out of the carpet, then the place where fell was cut out, burned, and a visible patch put down where it fell, and no one in that temple ever stood on that spot again.
It is my understanding that when the communion cloth is washed, the waste water is not carefully discarded in some place where a human foot will never tread. Some temples have special drains that go straight into the ground under the temple, and use the roots of dense hedges behind the church or similar places.