I agree with Shultz here. I too have made a rule of prayer using many of the Godly prayers from this Study Bible. The OSB has its limitations, no doubt. But if anyone looks at the OSB web-site you will see that they explain they followed some Protestant ideas in the original layout of the first edition (not to mention employing the Protestant NKJV). They did this, they explain, becuase they were venturing into some uncharted territory producing the first low cost, easily available, Orthodox Study Bible. In the new edition this reliance on Protestant format is being corrected.
The significance of this Bible to me is its presentation of Orthodox themes, theology, Tradition and Biblical interpretation. For instance take any dominant theme of Orthodoxy and beginning in the index of footnotes begin to trace where that theme is treated in the notes of the Bible. Then read the various Biblical citations along with the corresponding notes. I've done this many times and come away with much deeper Orthodox Biblical understanding of these particular Orthodox doctrines. THIS is why I like the OSB.
I realize that sometimes the notes are a tad clumsy and unimpressive but other times I have found them to be brilliant and very helpful. Again I know it has some short-commings, but when we consider its accessability, affordability, useability and general accuracy in presenting the basic Orthodox Faith, I think it is a God-send. The upcoming addition of the newly translated English Septuagint and revised NT text with revised notes will, in my opinion, make it even better.
p.s. As a side note, allow me to add that I have a brother-in-law who is in the process of re-discovering his Orthodox Christian faith (he is Antiochian Orthodox). He and his wife are doing much Bible study and he regularly listens to Protestant radio-evangelists, and reads Protestant Bible commentaries. Needles to say that Protestant doctrine is making its way into many of his understandings of Christianity (many times without him realizing it). You should have seen the look of surprise and astonishment when I was able (for twenty dollars) to place in his hands an Orthodox Study Bible. His comment to me was "I didn't even know something like this existed!" He thanked me profusely and further commented that he was wanting to know the way his Church understood the Bible. I know he will study this book assiduously and come away from it with a much better understanding of his Orthdox faith (as well as a safe-guard against Protestantsim). This is clear example of the importance and usefulness of this work.