St. Ignatius of Antioch Ephesians 4:9-10 ' For our God Jesus Christ was according to the dispensation of God conceived in the womb of Mary, of the seed of David, by the Holy Spirit; He was born and baptized, that through His passion He might purify water, to the washing away of sin. Now the Virginity of Mary, and He who was born of her, was kept in secret from the prince of this world; as was also the death of our Lord: three of the mysteries the most spoken of throughtout the world, yet done in secret by God'
again on his Epistle to Trallians 2:10-12 ' Stop your ears therefore as often as anyone shall speak contrary to Jesus Christ; who was of the race of David of the Virgin Mary. Who was truly born and did eat and drink; was truly persecuted under Pontius Pilate; was truly crucified and dead; both those in heaven and on earth, being spectators of it. Who was truly raised from the dead by his Father. after the same manner as He will also raise up us who believe in Him by Christ Jesus; without whom we have no true life.'
he repeats the same massage in his Epistle to the Smyraeans 1:4-5
St Ireanaeus as already stated by others on his book against Heresies Book I 7:1, Book III chapter 22:2-4, Book 5 chapter 1 and 19 he explains extensively on the matter , it truly is worthy of one's time and effort to read them all.
now I have great love for what the Harp of the Holy Spirit St.Ephraim has to say about the Theotokos in his beautiful hymns of the Nativity hymn 6,8,11,12 are my favorites I beg of you to read them if you have not already ,they are so beautiful!!
Of course St.Alexander , St.Athanasius and St.Cyril of Alexanderia ,St.Gregory the Theologian, St.Gregory of Nissa, St.Epiphanius of Salamis and many more have spoken in depth and with authority on the matter.