My paternal ancestry is Syrian, when was Antioch severed from what would be traditional Syria? Was it still part of an Ottoman ruled Syria for centuries or had it remained so with the Islamic takeover in the 7th c.?Weren't there 4 cities know as Antioch in the Biblical era?
at least. Tarsus have been renamed Antioch on the Cydnus by Antiochos IV, the Seleucids refounded Nisibis as Antioch Mygdonia, Anitioch in Pisisidia/Phrygia was where St. Paul founded the mission to the Gentiles (Acts 13:13–52), and there was an Antioch on the Meander.
Btw, here is a picture of around Antioch just under a century after the Ottoman conquest of it:
what is pictured is actually its suburb Daphne, there being little left of Antioch itself at the time, which would be above the center and to the right in the picture.