Most people who pray the Jesus Prayer pray it like any other prayer--no special practices in addition. This is different, I think, from "the practice of the Jesus Prayer," which people might read or hear about, which is, I think, frankly, beyond most people. With that specific practice, there are many who attempt it and should not. But, anyone can pray and live an Orthodox life and become a saint without exalted and perilous practices. The Jesus Prayer, in any case, is certainly not a mantra. Orthodox Christian prayer has little or nothing in common with Hindoo or Buddhist forms of prayer--it is even doubtful whether they can be called prayer. Our prayer is conversation with the Living God who knows our prayer before we ask Him, but who is pleased to listen to us for He desires a relationship--in which our salvation lies.