Author Topic: Windpipe transplant done using adult stem-cells...  (Read 2261 times)

0 Members and 1 Guest are viewing this topic.

Offline Fr. George

  • formerly "Cleveland"
  • Administrator
  • Stratopedarches
  • *******
  • Posts: 20,239
  • May the Lord bless you and keep you always!
  • Faith: Orthodox Christian
  • Jurisdiction: Greek Orthodox Metropolis of Pittsburgh
Windpipe transplant done using adult stem-cells...
« on: November 19, 2008, 10:54:11 AM »
Windpipe transplant breakthrough
By Michelle Roberts
Health reporter, BBC News

http://news.bbc.co.uk/2/hi/health/7735696.stm

Surgeons in Spain have carried out the world's first tissue-engineered whole organ transplant - using a windpipe made with the patient's own stem cells.

The groundbreaking technology also means for the first time tissue transplants can be carried out without the need for anti-rejection drugs.

Five months on the patient, 30-year-old mother-of-two Claudia Castillo, is in perfect health, The Lancet reports.

She needed the transplant to save a lung after contracting tuberculosis.

The disease had damaged her airways.

Scientists from Bristol helped grow the cells for the transplant and the European team believes such tailor-made organs could become the norm.

To make the new airway, the doctors took a donor windpipe, or trachea, from a patient who had recently died.

CT of the patient's lungs before
A pre-surgery CT - the arrow showing the windpipe narrowing

Then they used strong chemicals and enzymes to wash away all of the cells from the donor trachea, leaving only a tissue scaffold made of the fibrous protein collagen.

This gave them a structure to repopulate with cells from Ms Castillo herself, which could then be used in an operation to repair her damaged left bronchus - a branch of the windpipe.

(Click the link above for the rest of the article)

-------------------------------------------------------------------------------------------------------------------

Amazing stuff - and it used adult stem-cells (bonus for those of us who don't like embryonic stem-cell research).
"O Cross of Christ, all-holy, thrice-blessed, and life-giving, instrument of the mystical rites of Zion, the holy Altar for the service of our Great Archpriest, the blessing - the weapon - the strength of priests, our pride, our consolation, the light in our hearts, our mind, and our steps"
Met. Meletios of Nikopolis & Preveza, from his ordination.

Offline EofK

  • Mrs. Y
  • Protokentarchos
  • *********
  • Posts: 3,976
  • lolcat addict
Re: Windpipe transplant done using adult stem-cells...
« Reply #1 on: November 19, 2008, 11:07:29 AM »
Wow, that's incredible!
Human beings, who are almost unique in having the ability to learn from the experience of others, are also remarkable for their apparent disinclination to do so. -- Douglas Adams

Offline ytterbiumanalyst

  • Professor Emeritus, CSA
  • Merarches
  • ***********
  • Posts: 8,790
Re: Windpipe transplant done using adult stem-cells...
« Reply #2 on: November 19, 2008, 12:58:17 PM »
Awesome. This could help eliminate the waiting lists for transplants.
"It is remarkable that what we call the world...in what professes to be true...will allow in one man no blemishes, and in another no virtue."--Charles Dickens

Offline EofK

  • Mrs. Y
  • Protokentarchos
  • *********
  • Posts: 3,976
  • lolcat addict
Re: Windpipe transplant done using adult stem-cells...
« Reply #3 on: November 19, 2008, 12:59:49 PM »
Sort of, anyway.  The article mentioned that a donor windpipe was needed as a sort of template, though I don't think they said it needed to match blood types and all since it was stripped bare for the stem cells to grow.
Human beings, who are almost unique in having the ability to learn from the experience of others, are also remarkable for their apparent disinclination to do so. -- Douglas Adams

Offline ytterbiumanalyst

  • Professor Emeritus, CSA
  • Merarches
  • ***********
  • Posts: 8,790
Re: Windpipe transplant done using adult stem-cells...
« Reply #4 on: November 19, 2008, 01:08:21 PM »
Sort of, anyway.  The article mentioned that a donor windpipe was needed as a sort of template, though I don't think they said it needed to match blood types and all since it was stripped bare for the stem cells to grow.
Right, but people die all the time. If we didn't need to worry about rejection, we could really use any part from anyone to grow a new one.
"It is remarkable that what we call the world...in what professes to be true...will allow in one man no blemishes, and in another no virtue."--Charles Dickens

Offline EofK

  • Mrs. Y
  • Protokentarchos
  • *********
  • Posts: 3,976
  • lolcat addict
Re: Windpipe transplant done using adult stem-cells...
« Reply #5 on: November 19, 2008, 01:16:24 PM »
True, as long as people are still willing to be organ donors.
Human beings, who are almost unique in having the ability to learn from the experience of others, are also remarkable for their apparent disinclination to do so. -- Douglas Adams

Offline Fr. George

  • formerly "Cleveland"
  • Administrator
  • Stratopedarches
  • *******
  • Posts: 20,239
  • May the Lord bless you and keep you always!
  • Faith: Orthodox Christian
  • Jurisdiction: Greek Orthodox Metropolis of Pittsburgh
Re: Windpipe transplant done using adult stem-cells...
« Reply #6 on: November 19, 2008, 01:51:35 PM »
Sort of, anyway.  The article mentioned that a donor windpipe was needed as a sort of template, though I don't think they said it needed to match blood types and all since it was stripped bare for the stem cells to grow.

You're correct - it didn't need to match, since it was gutted except for the "skeletal structure" of the windpipe (empty cells and no blood).  Then the stem cells developed within the existing structure, taking on the characteristics and functions of the windpipe.

I think that this could lead to another increase in donor-ship, especially if people understand that there would now be more useful organs than ever before.
"O Cross of Christ, all-holy, thrice-blessed, and life-giving, instrument of the mystical rites of Zion, the holy Altar for the service of our Great Archpriest, the blessing - the weapon - the strength of priests, our pride, our consolation, the light in our hearts, our mind, and our steps"
Met. Meletios of Nikopolis & Preveza, from his ordination.

Offline ytterbiumanalyst

  • Professor Emeritus, CSA
  • Merarches
  • ***********
  • Posts: 8,790
Re: Windpipe transplant done using adult stem-cells...
« Reply #7 on: November 19, 2008, 02:56:59 PM »
True, as long as people are still willing to be organ donors.
Well, yes, of course.
"It is remarkable that what we call the world...in what professes to be true...will allow in one man no blemishes, and in another no virtue."--Charles Dickens

Offline antiderivative

  • Elder
  • *****
  • Posts: 349
Re: Windpipe transplant done using adult stem-cells...
« Reply #8 on: November 19, 2008, 05:38:29 PM »
So could this eliminate the controversy of stem cells by no longer requiring aborted fetuses?
signature

Offline Fr. George

  • formerly "Cleveland"
  • Administrator
  • Stratopedarches
  • *******
  • Posts: 20,239
  • May the Lord bless you and keep you always!
  • Faith: Orthodox Christian
  • Jurisdiction: Greek Orthodox Metropolis of Pittsburgh
Re: Windpipe transplant done using adult stem-cells...
« Reply #9 on: November 19, 2008, 05:40:09 PM »
So could this eliminate the controversy of stem cells by no longer requiring aborted fetuses?

I wish.  Alas, I don't think it will... There is more potential for "delicate" organs (i.e. the heart) from embryonic stem-cells than from adult stem cells.
"O Cross of Christ, all-holy, thrice-blessed, and life-giving, instrument of the mystical rites of Zion, the holy Altar for the service of our Great Archpriest, the blessing - the weapon - the strength of priests, our pride, our consolation, the light in our hearts, our mind, and our steps"
Met. Meletios of Nikopolis & Preveza, from his ordination.

Offline Riddikulus

  • Protokentarchos
  • *********
  • Posts: 4,788
Re: Windpipe transplant done using adult stem-cells...
« Reply #10 on: November 20, 2008, 12:56:14 AM »
That's amazing. I have heard that people here in Australia are being given the option of having their baby's placenta kept for future needs.
I believe in One God, maker of heaven and earth and of all things visible and invisible.

Nothing in biology makes sense except in the light of evolution.
Theodosius Dobzhansky, Russian Orthodox Christian (1900-1975)

Offline ialmisry

  • There's nothing John of Damascus can't answer
  • Strategos
  • ******************
  • Posts: 39,501
Re: Windpipe transplant done using adult stem-cells...
« Reply #11 on: November 20, 2008, 02:34:22 AM »
So could this eliminate the controversy of stem cells by no longer requiring aborted fetuses?

I wish.  Alas, I don't think it will... There is more potential for "delicate" organs (i.e. the heart) from embryonic stem-cells than from adult stem cells.
All this "potential" talk.  Adult stem cells have produced at least 70 treatments in hundreds of thousands of cases.  Embryonic stem-cells have yet to produce one treatment in one case.
Question a friend, perhaps he did not do it; but if he did anything so that he may do it no more.
A hasty quarrel kindles fire,
and urgent strife sheds blood.
If you blow on a spark, it will glow;
if you spit on it, it will be put out;
                           and both come out of your mouth

Offline ytterbiumanalyst

  • Professor Emeritus, CSA
  • Merarches
  • ***********
  • Posts: 8,790
Re: Windpipe transplant done using adult stem-cells...
« Reply #12 on: November 20, 2008, 08:26:00 AM »
^ Please, let's not discuss the embryonic stem-cell controversy here. We've already discussed it, and discussed it, and discussed it, and discussed it, and discussed it, and discussed it, and discussed it, and you get the idea. Let's leave this thread for a discussion of a medical breakthrough that has no controversy whatsoever.
"It is remarkable that what we call the world...in what professes to be true...will allow in one man no blemishes, and in another no virtue."--Charles Dickens

Offline minasoliman

  • Mr., Sir, Dude, Guy, Male, tr. Minas in Greek, Menes in white people Egyptologists :-P
  • Section Moderator
  • Hoplitarches
  • *****
  • Posts: 15,032
  • Strengthen O Lord the work of Your hands(Is 19:25)
Re: Windpipe transplant done using adult stem-cells...
« Reply #13 on: November 20, 2008, 01:13:35 PM »
Very promising stuff indeed.  Does anyone have any access to this article:

http://www3.interscience.wiley.com/journal/121501537/abstract

This seems to explain the history of how we arrived at stem cell production from differentiated cells.
Vain existence can never exist, for "unless the LORD builds the house, the builders labor in vain." (Psalm 127)

If the faith is unchanged and rock solid, then the gates of Hades never prevailed in the end.

Offline Starlight

  • Site Supporter
  • OC.net guru
  • *****
  • Posts: 1,537
Re: Windpipe transplant done using adult stem-cells...
« Reply #14 on: November 21, 2008, 12:53:14 AM »
Excellent accomplishments. Incredible!