Just a few cents from my own not so great experiences with house blessings and a non-orthodox spouse. 15 years ago when my priest came to bless our home for the first time (it was the first house blessing after my christmation), I didn't really know the drill and what to expect. Well, the priest stuck a candle in my husband's hand and asked him to lead the procession as we sang the troparion. My husband had told me he didn't want to participate and I had not really known how to step into the subject since Father just got right down to business. My husband finished the blessing without any blow up but I sure heard about it afterwards. He felt like he'd been ambushed and I hadn't respected his feelings. He has never participated in a house blessing since then and has made himself very scarce every year. So, my advice to anyone is to make sure you explain to your priest beforehand what the other spouse's feelings are about the houseblessing, the extent of their participation, and any questions or objections your spouse might have. That way no one gets put in an awkward situation and peace is maintained for what should be a very peaceful and meaningful event. If your spouse doesn't want to participate at least see if they will stick around and have coffee and cake afterwards. This is a good time for your priest to gently broach the subject of any questions the spouse might have, or just to give your spouse the time to meet your priest and find out he's not some weird guy in robes but a real person who more than likely has dealt with these kinds of objections to house blessings or Orthodoxy in general.
Hope this helps.
(From San Antonio, Texas, where we are praying for "unseasonable" weather tomorrow so we get a day off work - it's not too much to ask for one ice day a year and you certainly don't want to waste it on a weekend or holiday!)